A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/4409 (2006.01) A61K 31/495 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2386725
A pharmaceutical composition of anti-tubercular drugs for oral use comprising Rifampicin and/or Isoniazid wherein the bioavailability of Rifampicin and/or other drugs is enhanced. Preferably the bioavailability of Rifampicin is enhanced by preventing its degradation caused by presence of Isoniazid. Rifampicin and/or Isoniazid may be present in delayed release and/or extended release form such that minimal amount of the drug is dissolved between pH 1 and 4. preferably delayed release of Rifampicin and/or Isoniazid is achieved by treating the drugs with pH sensitive polymers.
L'invention concerne une composition pharmaceutique de médicaments contre la tuberculose, destinée à l'administration orale et comprenant Rifampicine et/ou Isoniazide, la biodisponibilité de Rifampicine et/ou d'autres médicaments étant améliorée. De préférence, on a amélioré la biodisponibilité de Rifampicine en empêchant sa dégradation provoquée par la présence d'Isoniazide. Rifampicine et/ou Isoniazide peuvent être présents sous forme de préparation à libération retardée et/ou prolongée, de manière à ce qu'une quantité minimale du médicament soit dissoute avec un pH entre 1 et 4. De préférence, on obtient la libération retardée de Rifampicine et/ou Isoniazide en traitant les médicaments avec des polymères sensibles à pH.
Jain Rajesh
Singh Amarjit
Panacea Biotec Limited
Sim & Mcburney
LandOfFree
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