Galnts as modifiers of the igfr pathway and methods of use

Details Galnts as modifiers of the igfr pathway and methods of use Galnts as modifiers of the igfr pathway and methods of use

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) C12P 21/04 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2571250

Human GALNT genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of GALNT are provided.

Des gènes GALNT humains sont identifiés comme modulateurs du chemin IGFR, et sont ainsi des cibles thérapeutiques pour des troubles associés à une fonction IGFR défectueuse. La présente invention concerne donc des procédés permettant d'identifier des modulateurs d'IGFR, avec recherche par criblage d'agents modulant l'activité de GALNT.

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