Modified il-12 subunits and nucleic acids encoding them

Details Modified il-12 subunits and nucleic acids encoding them Modified il-12 subunits and nucleic acids encoding them

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) C07K 14/54 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2389262

New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic acids, methods of making the polypeptides and nucleic acid, antibodies to the polypeptides, and methods of using the polypeptides and nucleic acids are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are also provided.

L'invention concerne de nouveaux polypeptides cytokines ainsi que les acides nucléiques codant pour eux. L'invention concerne également des compositions comprenant ces polypeptides et ces acides nucléiques, des cellules recombinées comprenant ces polypeptides et ces acides nucléiques, des méthodes de fabrication de ces polypeptides et de ces acides nucléiques, des anticorps dirigés contre ces polypeptides ainsi que des méthodes d'utilisation de ces polypeptides et de ces acides nucléiques. L'invention concerne en outre des systèmes intégrés comprenant les séquences de ces acides nucléiques ou de ces polypeptides.

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