C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07D 335/06 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 419/06 (2006.01)
Patent
CA 2256718
A compound having structure (I) wherein (a) X is selected from the group consisting of O, S, SO, or SO2; (b) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 4 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (d) W is O or S; and (e) R is straight, branched or cyclic alkyl or aryl, saturated or mono- or di-unsaturated with double or triple bonds, R having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
L'invention concerne un composé ayant la structure (I) dans laquelle (a) X est choisi dans le groupe composé de O, S, SO, ou bien SO2; (b) chaque Y est indépendamment hydrogène ou bien un alcanyle droit, ramifié ou cyclique possédant de 1 à 4 atomes de carbone, ou encore les deux Y sont liés pour former un noyau alcanyle ayant de 3 à environ 7 atomes de carbone; (c) est un alkyle ramifié ou cyclique ayant de 3 à environ 10 atomes qui ne sont pas de l'hydrogène; (d) W est O ou S; et (e) R est un alkyle ou un aryle droit, ramifié ou cyclique, saturé ou mono- ou di-insaturé avec des liaisons doubles ou triples, R ayant de 1 à environ 15 atomes qui ne sont pas de l'hydrogène. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, ainsi que des méthodes pour traiter l'inflammation ou la douleur à l'aide de ces derniers.
Janusz John Michael
Johnson Carl Randolph
Senanayake Chandrawansha Bandara W.
Kirby Eades Gale Baker
The Procter & Gamble Company
Vanderbilt University
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