Novel recombinant temperature sensitive mutants of influenza

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/44 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2423891

Recombinant PB2 variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.

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