Modular recombinatorial display libraries

Details Modular recombinatorial display libraries Modular recombinatorial display libraries

C - Chemistry, Metallurgy

12

N

C12N 15/66 (2006.01) C07H 21/00 (2006.01) C12N 7/01 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2477947

Modular display libraries are disclosed characterized by a display having two or more variable regions connected with constant regions encoded by DNA segments that include a restriction endonuclease cleavage site. The segments encoding modular variable regions can be recombined in anther position in the display vector or rearranged to extend the diversity of the original modular library.

L'invention porte sur des banques d'affichage modulaires caractérisées par un affichage présentant au moins deux zones variables reliées à des zones constantes codées par des segments d'ADN qui comprennent un site de clivage d'endonucléase de restriction. Les segments de codage des zones variables modulaires peuvent être recombinés dans une position d'anthères dans le vecteur d'affichage ou redisposés afin d'étendre la diversité de la banque modulaire originale.

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