Indolin-2-ones and aza-indolin-2-ones

Details Indolin-2-ones and aza-indolin-2-ones Indolin-2-ones and aza-indolin-2-ones

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/529 (2006.01) A61P 15/16 (2006.01) A61P 35/00 (2006.01) C07D 487/18 (2006.01) C07D 487/22 (2006.01) C07D 498/22 (2006.01) C07D 513/08 (2006.01) C07D 513/18 (2006.01) C07D 513/22 (2006.01)

Patent

CA 2687909

The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to certain indolin-2-ones and aza-indolin-2-ones which possess anti-tumour activity and are accordingly useful in methods of treatment of the human or animal body, in particular such compounds are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis. Formula (I) a N-oxide form, a quaternary anime or a stereochemically isomeric form thereof, wherein Z represents N or CH.

La présente invention porte sur des composés ou des sels acceptables du point de vue pharmaceutique de ceux-ci, sur des procédés permettant de les préparer, sur des compositions pharmaceutiques les contenant et sur leur utilisation en thérapie. En particulier, l'invention porte sur certaines indolin-2-ones et aza-indolin-2-ones qui possèdent une activité anti-tumorale et qui, par conséquent, s'utilisent dans des procédés de traitement du corps humain ou animal. En particulier, de tels composés s'utilisent dans le traitement de processus pathologiques qui mettent en jeu une prolifération cellulaire aberrante, tels qu'une croissance tumorale, l'arthrite rhumatoïde, la resténose et l'athérosclérose.

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