C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 17/02 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2678755
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114, 116, 117, 121, 395, 133, 135, 137, 426, 174, 178, 186, 194, 196, 202, 210, 213, 214, 217, 223, 227, 228, 233, 254, 271, 272 or 288, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several (e.g., up to 5) amino acids are substituted, deleted, or added, provided the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with over-expression of the CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK and/or URLC10, e.g. cancers containing as an active ingredient one or more of these peptides. The peptides of the present invention find further utility as vaccines.
La présente invention concerne des peptides ayant une séquence d'acide aminé comme indiqué dans la SEQ ID NO: SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114, 116, 117, 121, 395, 133, 135, 137, 426, 174, 178, 186, 194, 196, 202, 210, 213, 214, 217, 223, 227, 228, 233, 254, 271, 272 ou 288, ainsi que des peptides ayant les séquences d'acide aminé mentionnées ci-dessus dans lesquelles 1, 2, ou plus (par exemple jusqu'à 5) acides aminés sont substitués, effacés, ou ajoutés, à condition que les peptides possèdent une inductibilité de cellule T cytotoxique. La présente invention propose également des médicaments pour traiter ou prévenir une maladie associée à une surexpression des CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK et/ou URLC10, par exemple les cancers, contenant comme ingrédient actif un ou plusieurs de ces peptides. Les peptides de la présente invention sont également utiles comme vaccins.
Ohsawa Ryuji
Tsunoda Takuya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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