C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/19 (2006.01) C12N 15/65 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01) C12Q 1/68 (2006.01) C40B 30/06 (2006.01) C40B 40/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2653948
The present invention relates in general to the fields of chemical, pharmaceutical and genetic screening and to diseases associated with protein misfolding. In particular, it discloses engineered cells and a system based thereon that can be used to screen for substances that affect protein misfolding. The engineered cells of the invention comprise one or more reporter genes under transcriptional control of a promoter that is responsive to protein misfolding.
La présente invention concerne d'une manière générale les domaines du criblage chimique, pharmaceutique et génétique ainsi que des maladies associées au mauvais repliement de protéines. L'invention concerne en particulier des cellules modifiées par génie génétique et un système basé sur celles-ci, qui peut être utilisé pour le criblage de substances affectant le mauvais repliement de protéines. Les cellules modifiées par génie génétique selon l'invention contiennent un ou plusieurs gènes rapporteurs sous la régulation transcriptionnelle d'un promoteur responsable du mauvais repliement de protéines.
Coupet Kristel Marie Edith
Griffioen Gerard
Van Damme Nele
Wera Stefaan
Nv Remynd
Smart & Biggar
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