Pyrimidine derivatives

Details Pyrimidine derivatives Pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 9/08 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2462799

Pyrimidine derivatives of formula (I) and the physiologically acceptable salts thereof, where R1, R2, R3, R4, W, X, Y and Z have the meanings given in claim 1, display a phosphodiesterase V inhibition and can be used for treatment of diseases of the coronary circulatory system and for treatment and/or therapy of potency disorders.

L'invention concerne des dérivés de pyrimidine correspondant à la formule (I), ainsi que les sels physiologiquement compatibles de ces dérivés. Dans ladite formule (I), R1, R2, R3, R4, W, X, Y et Z correspondent à la définition donnée dans la revendication 1. Ces dérivés et leurs sels physiologiquement compatibles présentent une activité inhibitrice de la phosphodiestérase V et peuvent être utilisés dans le traitement de maladies du système cardio-vasculaire et dans le traitement et/ou la thérapie de l'impuissance.

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