Genomic modifications with homologous dna targeting

Details Genomic modifications with homologous dna targeting Genomic modifications with homologous dna targeting

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) A61K 48/00 (2006.01) C07K 14/805 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092695

2092695 9220808 PCTABS00017 Methods are provided for modification of genomic target sites, where desired changes which can be small or subtle may be introduced into the target site to provide for modification of target genes or regulatory sequences. It is found that one may retain a marker without interference with the functioning of a target gene or select for excision of exogenous DNA to leave a single copy of the target gene with the modification.

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