Inhibitors of herpes viral ribonucleotide reductase

Details Inhibitors of herpes viral ribonucleotide reductase Inhibitors of herpes viral ribonucleotide reductase

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 14/035 (2006.01) A61K 38/00 (2006.01) A61K 7/48 (1995.01)

Patent

CA 2157196

Disclosed herein are peptide derivatives of the formula A-B-D- NHCH{CH2C(O)R1}C(O)NHCH{CR2(R3)-COOH}C(O)-E wherein A is a lower alkanoyl bearing two substituents, each substituent selected independently from phenyl or a monosubstituted phenyl wherein the monosubstituent is alkyl, halo, hydroxy or alkoxy; B is an N-methyl amino acid residue; D is an amino acid residue; R1 is alkyl, cycloalkyl, a monosubstituted amino or a disubstituted amino; R2 is hydrogen or alkyl and R3 is alkyl, or R2 and R3 are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections.

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