Di-aryl ethers and their derivatives as anti-cancer agents

Details Di-aryl ethers and their derivatives as anti-cancer agents Di-aryl ethers and their derivatives as anti-cancer agents

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/085 (2006.01) A61K 31/09 (2006.01) A61K 31/095 (2006.01) A61K 31/10 (2006.01) A61K 31/11 (2006.01) A61K 31/12 (2006.01) A61K 31/235 (2006.01) A61K 31/65 (2006.01) A61K 41/00 (2006.01) C07C 45/29 (2006.01) C07C 47/575 (2006.01) C07C 65/24 (2006.01) C07C 205/59 (2006.01)

Patent

CA 2285530

The present invention relates, inter alia, to compounds that bind tubulin and exhibit anti-mitotic properties and to methods of using such compounds to inhibit abnormal cell mitosis and, in particular, to inhibit tumor cell growth. In addition, methods are presented of treating mammalian diseases associated with undesired and uncontrolled angiogenesis.

La présente invention porte, entre autre, sur des composés qui fixent la tubuline et présentent des propriétés antimitotiques, et sur des procédés d'utilisation de ces composés destinés à inhiber la mitose des cellules étrangères, et notamment la prolifération cellulaire. De plus, ces procédés sont destinés à traiter les maladies mammaliennes associées à l'angiogenèse indésirable et non maîtrisée.

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