C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A61K 39/09 (2006.01) C07K 16/12 (2006.01) C08B 37/00 (2006.01) C12P 19/04 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2198251
Immunogenic polysaccharide-protein conjugates are generated which have an oxidized polysaccharide derived from the capsular polysaccharide of Streptococcal pneumoniae and the pneumolysin protein of S. pneumoniae wbich is expressed recombinantly. The pneumolysin is not toxoided prior to conjugation with said oxidized polysaccharide. The immunogenic conjugates are used as vaccines to elicit antibody responses to the capsular polysaccharide of S. pneumoniae and to recombinant pneumolysin, and to immunize against S. pneumoniae-caused disease.
L'invention se rapporte à la production de conjugués immunogènes comprenant un polysaccharide et une protéine, le polysaccharide oxydé étant dérivé du polysaccharide capsulaire de la pneumopathie à streptocoques Streptococcal pneumoniae et de la protéine de la pneumolysine de S. pneumoniae qui est exprimée par recombinaison. La pneumolysine n'est pas soumise à l'action des anatoxines avant sa conjugaison avec le polysaccharide oxydé. Les conjugués immunogènes sont utilisés comme vaccins pour provoquer des réponses d'anticorps dirigées contre le polysaccharide capsulaire de S. pneumoniae et contre la pneumolysine de recombinaison, et pour immuniser ainsi contre les maladies provoquées par S. pneumoniae.
Kuo Joseph S.-C.
Ree Heesoo K.
American Cyanamid Company
Smart & Biggar
Wyeth Holdings Corporation
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