Process for the preparation of optically active...

C - Chemistry – Metallurgy – 07 – D

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C07D 241/04 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2201218

Optically active piperazine-2-carboxylic acid derivatives of the general formula: (see formula I) in which X is alkoxy or a (substituted) amino group, are prepared by asymmetric hydrogenation of the corresponding pyrazinecarboxylic acid derivatives, catalysed by optically active rhodium complexes. The compounds of formula I are intermediates for the preparation of pharmaceutical active substances, for example HIV protease inhibitors.

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