Soluble icam-1 as biomarker for prediction of therapeutic...

G - Physics – 01 – N

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G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2749192

The present invention re-lates to the field of immunology and, in particular, to a vaccination procedure for treatment of a patient against dis-eases caused for example by infection or cancers. More particularly, the invention relates to methods for predicting whether a subject is or is not susceptible to developing a prophylactic or thera-peutic response, preferably immune re-sponse, after such vaccination. The present invention relates to methods and compositions for selecting patients best able to raise a therapeutic immune re-sponse in vivo by an immunogenic com-position, in particular a vaccine.

La présente invention concerne le domaine de l'immunologie et notamment une procédure de vaccination destinée au traitement d'un patient contre des maladies causées, par exemple, par une infection ou des cancers. La présente invention concerne plus particulièrement des procédés de prédiction de la prédisposition ou non d'un sujet à développer une réponse prophylactique ou thérapeutique, de préférence une réponse immunitaire, après une telle vaccination. La présente invention concerne des procédés et des compositions de sélection de patients les plus susceptibles de développer une réponse immunitaire thérapeutique in vivo avec une composition immunogène, en particulier un vaccin.

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