Glucagon receptor antagonists, preparation and therapeutic uses

Details Glucagon receptor antagonists, preparation and therapeutic uses Glucagon receptor antagonists, preparation and therapeutic uses

C - Chemistry, Metallurgy

07

C

C07C 233/83 (2006.01) A61K 31/166 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2629223

The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

La présente invention concerne de nouveaux composés de formule (I), ou des sels pharmaceutiquement acceptables de ces composés, présentant une activité agoniste inverse ou antagoniste des récepteurs du glucagon, ainsi que des procédés de préparation de ces composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant des composés de formule (I) ainsi que leurs méthodes d'utilisation pour traiter le diabète et d'autres troubles métaboliques associés au glucagon, et analogues.

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