Low-voltage activated calcium channel compositions and methods

Details Low-voltage activated calcium channel compositions and methods Low-voltage activated calcium channel compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2312195

Isolated nucleic acid encoding low voltage activated calcium channel subunits, including subunits encoded by nucleic acid that arises as splice variants of primary transcripts, is provided. Cells and vectors containing the nucleic acid and methods for identifying compounds that modulate the activity of calcium channels that contain these subunits are also provided.

L'invention se rapporte à un acide nucléique isolé codant pour des sous-unités de canaux calcium activés à basse tension, et notamment des sous-unités codées par l'acide nucléique qui permet d'isoler des allèles d'épissure de produits de transcription primaires. L'invention se rapporte également à des cellules et à des vecteurs contenant ledit acide nucléique et à des procédés d'identification de composés qui modulent l'activité des canaux calcium et contiennent ces sous-unités.

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