C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/64 (2006.01) A61K 31/196 (2006.01) A61K 31/606 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2656216
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.
La présente invention porte sur des compositions et des méthodes permettant de prévenir des maladies neurologiques accompagnées d'une mort neuronale. L'invention comprend la synthèse d'acide 5-benzylamino salicylique (BAS) et de ses dérivés. Le BAS et ses dérivés protègent les neurones corticaux d'agressions toxiques infligées par le N-methyl-D-aspartate, le Zn2+ et les espèces réactives de l'oxygène. Par conséquent, la présente invention propose des compositions et des méthodes permettant de traiter les ACV, les traumatismes cérébraux et les lésions de la moelle épinière, l'épilepsie et les maladies neurodégénératives accompaniées d'une perte neuronale grave causée par une excitotoxicité, une neurotoxicité au Zn2+ et une neurotoxicité aux radicaux libres.
Gwag Byoung Joo
Lee Young Ae
Moon Ho Sang
Ryu Bo Rum
Yoon Sung Hwa
Neurotech Co. Ltd.
Sim & Mcburney
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