C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/54 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C09B 23/01 (2006.01) G01N 1/30 (2006.01) G01N 33/52 (2006.01)
Patent
CA 2189125
Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis[4-(4, 5, 6, 7 tetrahydro-1H-1,3-diazepin-2-yl)phenyl]furan; 2,5-bis?[4-(N- isopropyl)amidino]phenyl}furan; and physiogically acceptable salts thereof,and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
Cette invention se rapporte à un procédé de détection fluorescente d'un acide nucléique. Ce procédé consiste à mettre en contact avec l'acide nucléique un composé de furanne arylique bis-dicationique, tel que 2,5-bis[4-(4,5,6,7-tétrahydro-1H-1,3-diazépine-2-yl)phényl]furanne; 2,5-bis{[4-(N-isopropyl)amidino]phényl}furanne; et des sels physiologiquement acceptables de ce composé; puis à exposer cet acide nucléique à de la lumière à une fréquence propre à induire la fluorescence dudit composé. Un procédé de détection fluorescente d'éléments de cytosquelettes ainsi que de nouveaux composés de furannes aryliques bis-dicationiques sont également décrits.
Boykin David W.
Das Bijan P.
Dykstra Christine C.
Kumar Arvind
Spychala Jaroslaw
Sim & Mcburney
The Georgia State University Research Foundation Inc.
University Of North Carolina At Chapel Hill
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