C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/16 (2006.01) A61K 39/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/125 (2006.01) C12N 7/08 (2006.01)
Patent
CA 2458543
The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.
la présente invention concerne des souches virales lentogéniques utiles pour le traitement du cancer. Une souche virale préférée du virus de la maladie de Newcastle (VMN) est caractérisé spécifiquement en termes d'activités biologiques. Cette invention porte également sur le traitement du cancer par application de souches VMD clonales à des tumeurs. Dans un autre mode de réalisation préféré, le traitement du cancer fait intervenir au moins une protéine virale isolée, ou bien une sous-unité ou un analogue de ladite protéine, ou bien encore un polynucléotide isolé codant pour cette protéine.
Irving Charles
Panet Amos
Zakay-Rones Zichria
Ovcure Inc.
Ridout & Maybee Llp
Theravir Management L.p.
Yissum Research Development Company
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