Ciz1 splice variants

Details Ciz1 splice variants Ciz1 splice variants

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2507403

This invention relates to a screening method for the identification of agents which modulate the activity of the CIZ1 DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g.,cancer.

L'invention se rapporte à un procédé de criblage permettant d'identifier des agents modulant l'activité d'une protéine de réplication de l'ADN servant de cible pour une intervention dans une thérapie contre le cancer et comportant des agents modulant ladite activité. L'invention se rapporte également à l'utilisation d'une protéine de réplication de l'ADN, et à ses produits de la transcription de l'ARN dans le pronostic et le diagnostic de maladies proliférantes, notamment le cancer.

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