Self-microemulsifying drug delivery systems of a hiv...

Details Self-microemulsifying drug delivery systems of a hiv... Self-microemulsifying drug delivery systems of a hiv...

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/635 (2006.01)

Patent

CA 2549462

The present invention relates to pharmaceutical formulations of (3R,3aS,6aR)~- hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate, salts, esters, polymorphic and pseudopolymorphic forms thereof, which are self- microemulsifying drug delivery systems and comprise as carrier a lipophilic phase, one or more surfactants, a hydrophilic solvent and a nucleation inhibitor.

La présente invention concerne des formulations pharmaceutiques de (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophényl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate, leurs sels, esters, formes polymorphes et pseudopolymorphes, lesquelles constituent des systèmes d'administration de médicaments à auto-microémulsion et comprennent en tant qu'excipient une phase lipophile, un ou plusieurs tensioactifs, un solvant hydrophile et un inhibiteur de nucléation.

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