Human colon cancer associated gene sequences and polypeptides

Details Human colon cancer associated gene sequences and polypeptides Human colon cancer associated gene sequences and polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2366174

This invention relates to newly identified colon or colon cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "colon cancer antigens", and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such colon cancer antigens for detection, prevention and treatment of disorders of the colon, particularly the presence of colon cancer. This invention relates to the colon cancer antigens as well as vectors, host cells, antibodies directed to colon cancer antigens and recombinant and synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of colon cancer antigens of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and/or function of the polypeptides of the present invention.

Cette invention porte sur des polynucléotides récemment identifiés et associés au cancer du côlon, et sur les polypeptides codés par ces polynucléotides et connus collectivement sous le nom <= d'antigènes du cancer du côlon>=. L'invention porte également sur les séquences géniques complètes associées et sur leurs produits d'expression, ainsi que sur l'utilisation de ces antigènes du cancer du côlon dans la détection, la prévention et le traitement des pathologies spécifiques d'un tissu telles que le cancer. Cette invention porte sur les antigènes du cancer, ainsi que sur les vecteurs, les cellules hôtes, les anticorps dirigés contre les antigènes du cancer et sur des procédés recombinants et synthétiques de production de ces anticorps. L'invention porte également sur des procédés de diagnostic permettant de diagnostiquer et traiter, prévenir et/ou établir un pronostic de pathologies du côlon telles que le cancer, et sur des procédés thérapeutiques visant à traiter ces pathologies. Cette invention porte en outre sur des procédés de recherche automatique visant à identifier des agonistes et des antagonistes des antigènes du cancer du côlon, et sur des procédés et/ou des compositions visant à inhiber la production et/ou la fonction des polypeptides de cette invention.

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