Reducing conjugative plasmids in bacteria

C - Chemistry – Metallurgy – 12 – N

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C12N 7/00 (2006.01) A61K 35/76 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2718052

The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying ad-ditional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.

La présente invention concerne des procédés et des compositions pour réduire la prévalence de plasmides dans des colonies microbiennes, y compris des infections, et comprend des compositions thérapeutiques, des méthodes de traitement dinfections et des procédés pour identifier de telles autres compositions. Des moyens sont utilisés pour réduire le nombre dexemplaires de gènes résistants aux antibiotiques et pour conférer une liaison aux phages à des cellules qui manquent de récepteurs pour ces phages.

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