C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/565 (2006.01) A61K 38/00 (2006.01) A61K 38/21 (2006.01) A61K 47/30 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2565375
PEG-IFN-.beta.; conjugates, where a PEG moiety is covalently bound to Cys 17 of human IFN-.beta;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-.beta..
El Tayar Nabil
Harris Milton
Roberts Michael J.
Sawlivich Wayne
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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