Substituted polycyclic aryl and heteroaryl pyrymidinones...

Details Substituted polycyclic aryl and heteroaryl pyrymidinones... Substituted polycyclic aryl and heteroaryl pyrymidinones...

C - Chemistry, Metallurgy

07

D

C07D 239/46 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01) C07D 253/06 (2006.01) C07D 253/07 (2006.01) C07D 401/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2373614

The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

L'invention concerne des composés de pyrimidinone aryle et hétéroaryle polycycliques substitués utilisés comme inhibiteurs de sérine protéases de la cascade de coagulation, ainsi que des composés, des compositions et des méthodes utilisés dans la thérapie anticoagulante pour le traitement et la prévention de nombreux états thrombotiques, tels que les coronaropathies et les affections cérébrovasculaires.

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