Modulators of methylation for control of bacterial virulence

Details Modulators of methylation for control of bacterial virulence Modulators of methylation for control of bacterial virulence

A - Human Necessities

61

K

A61K 38/51 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2375383

Compositions and methods which ameliorate the virulence of bacterial infection are described wherein the active ingredient modulates transmethylation reactions in bacterial cells. Particularly useful compounds are inhibitors of S-adenosyl me-thionine synthetase (SAMS), of S-adenosyl homocysteine hydrolase (SAHH) and of transmethylases.

On décrit des compositions et des procédés qui permettent d'améliorer la virulence d'une infection bactérienne, l'ingrédient actif de ces compositions modulant les réactions de transméthylation dans des cellules de bactéries. Les composés particulièrement utiles sont les inhibiteurs de la S-adénosyle méthionine synthétase (SAMS), de la S-adénosyle homocystéine hydrolase (SAHH) et des transméthylases.

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