C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61K 47/48 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) C07K 17/08 (2006.01)
Patent
CA 2674354
Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
L'invention concerne des peptides de type glucagon qui présentent une solubilité améliorée tout en maintenant l'activité agoniste du glucagon. Le peptides glycogéniques ont été modifiés par substitution d'acides aminés natifs avec et/ou addition d'acides aminés chargés à la terminaison carboxy du peptide. Les agonistes du glucagon modifiés peuvent être modifiés de nouveau par pégylation ou par l'addition d'un peptide à terminaison carboxy sélectionné dans le groupe constitué par les séquences SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, ou leur combinaison pour améliorer davantage la solubilité d'analogues des agonistes du glucagon.
Chabenne Joseph
Dimarchi Maria
Dimarchi Richard D.
Indiana University Research And Technology Corporation
Smart & Biggar
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