Nanoparticulate tadalafil formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 31/4985 (2006.01)

Patent

CA 2622200

The present invention is directed to compositions comprising nanoparticulate tadalafil, or a salt or derivative thereof, having improved bioavailability, faster rates of absorption and a faster onset of therapeutic effect. The nanoparticulate tadalafil particles of the composition are proposed to have an effective average particle size of less than about 2000 nm and may be useful in the treatment of sexual dysfunction and vascular-, pulmonary- and cardiac- related diseases and conditions.

La présente invention porte sur des compositions comprenant un tadalafil nanoparticulaire ou un sel ou un dérivé de celui-ci ayant une meilleure biodisponibilité, des vitesses d'absorption plus rapides, ainsi qu'un effet thérapeutique plus rapide. Les particules nanoparticulaires du tadalafil de la composition ont une granulométrie moyenne effective inférieure à environ 2000 nm et peuvent être utiles dans le traitement d'une dysfonction sexuelle et de maladies et états vasculaires, pulmonaires et cardiaques.

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