C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2406247
This invention is directed to novel sulfonamide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the structure shown in Figure 1, wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
L'invention concerne des nouveaux composés inhibiteurs, de la famille ICE/ced-3, à base de dipeptidyle d'acyle (substitué) de sulfonamide, possédant la structure montrée sur la figure (1), dans laquelle A, B, X, R, R?1¿, R?2¿, <i>n</i>, <i>q</i>, et <i>r</i> possèdent les notations données dans la description. L'invention concerne également des compositions pharmaceutiques contenant ces composés, de même que l'utilisation de ces compositions dans le traitement de patients soufrant de maladies inflammatoires, auto-immunes ou neurodégénératives, dans la prévention de lésions ischémiques, ainsi que dans la préservation d'organes soumis à une procédure de transplantation.
Gladstone Patricia L.
Ternansky Robert J.
Tomaselli Kevin J.
Gowling Lafleur Henderson Llp
Idun Pharmaceuticals Inc.
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