Therapeutic applications of pro-apoptotic benzodiazepines

Details Therapeutic applications of pro-apoptotic benzodiazepines Therapeutic applications of pro-apoptotic benzodiazepines

C - Chemistry, Metallurgy

07

D

C07D 243/24 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01) A61P 37/06 (2006.01) C07D 243/14 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2372150

Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1.4- benzodiazepine-2,5-dione compounds of structures (I) or (II): wherein R1, R2, R3 and R4 are as defined. The invention also includes enantiomers, pharmaceutically acceptable salts, prodrugs or derivatives of the benzodiazepine compounds. Any one or more of these benzodiazepine compounds can be used to treat a variety of dysregulatory disorders related to cellular death. Such disorders include autoimmune disorders, inflammatory conditions, hyperproliferative conditions, viral infections, and atherosclerosis. In addition, the above compounds can be used to prepare medicaments to treat the above-described dysregulatory disorders. The benzodiazepines can also be used in drugs screening assays and other diagnostic methods.

L'invention concerne des composés de benzodiazépine et des méthodes d'utilisation de ceux-ci. Certains de ces composés de benzodiazépine renferment des composés de 1,4-benzodiazépine-2-one et de 1,4-benzodiazépine-2,5-dione des structures: (I) ou (II), dans lesquelles R¿1?, R¿2?, R¿3? et R¿4? sont tels que définis dans la description. Cette invention concerne également des énantiomères, des sels pharmaceutiquement acceptables, des promédicaments ou des dérivés desdits composés de benzodiazépine. Un ou plusieurs de ces composés de benzodiazépine peuvent être utilisés pour traiter différentes dysrégulations liées à la mort cellulaire, par exemple les maladies auto-immunes, les états inflammatoires ou hyperprolifératifs, les infections virales, et l'athérosclérose. Les composés de cette invention peuvent par ailleurs être utilisés pour préparer des médicaments destinés à traiter les dysrégulations susmentionnées, les benzodiazépines servant également dans des essais de criblage de médicaments et d'autres méthodes diagnostiques.

Affiliated with

Also associated with

Rating

Therapeutic applications of pro-apoptotic benzodiazepines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic applications of pro-apoptotic benzodiazepines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic applications of pro-apoptotic benzodiazepines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1843946