4-aminoethoxy indolone derivatives

Details 4-aminoethoxy indolone derivatives 4-aminoethoxy indolone derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/40 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2264078

A compound of formula (I) in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or - (CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2- thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3- dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

Composé de formule (I) où Y est hydrogène, halogène ou alcoxy inférieur; R¿1? est hydrogène, alkyle inférieur ou arylalkyle(inférieur); R¿2? est hydrogène, alkyle inférieur ou -(CH¿2?)¿n?X¿p?Ar, où X est oxygène ou carbonyle; Ar est cycloalkyle, aryle ou arylaryle, oxindolyle, benzimidazolyle, indolyle, 2-oxobenzimidazolyle ou 2-thioxobenzimidazolyle; ou R¿1? et R¿2? pris avec l'atome d'azote auquel ils sont attachés complètent un 3,4-dihydro-1H-isoquinolinyle ou 1,3-dihydro-isoindolyle; n est un intègre choisi parmi 1,2,3,4,5 ou 6; p est l'un des intègres zéro ou un; ou son sel pharmaceutiquement acceptable, qui agissent en tant qu'inhibiteurs de la synthèse et de la libération de dopamine et peuvent s'utiliser dans le traitement de la schizophrénie, de la maladie de Parkinson, de la maladie de Gilles de La Tourette, de l'alcoolisme, de la cocaïnomanie et de l'assuétude à des drogues similaires.

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