Splice variants of erbb ligands, compositions and uses thereof

Details Splice variants of erbb ligands, compositions and uses thereof Splice variants of erbb ligands, compositions and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 17/02 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/485 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2536146

The present invention relates to nucleic acid and amino acid sequences of previously unknown ErbB ligands that are splice variants of previously known ErbB ligands, to compositions comprising these sequences and uses thereof in the diagnosis, treatment, and prevention of diseases and disorders mediated by ErbB receptors. Specifically, the present invention relates to splice variants lacking the C-loop of an intact EGF domain.

L'invention concerne des séquences d'acides nucléiques et d'acides aminés de ligands ErbB inconnus auparavant. Ces ligands sont des variants d'épissage de ligands ErbB connus auparavant. L'invention concerne également des compositions contenant lesdites séquences, ainsi que les utilisations de ces compositions dans le diagnostic, le traitement et la prévention de maladies et de troubles à médiation de récepteurs ErbB. L'invention concerne en particulier des variants d'épissage dépourvus de la boucle C d'un domaine EGF intact.

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