Thimerosal-free preservatives for vaccines

Details Thimerosal-free preservatives for vaccines Thimerosal-free preservatives for vaccines

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2278684

Novel combination of preservatives (methyl and propyl parabens, benzyl alcohol, and 2-phenoxyethanol) were found to pass antimicrobial testing according to USP, BP, and EP. The new preservatives were put into vaccines using L-histidine as a buffer to keep p11 at 7Ø HPLC methods were developed to analyze these preservatives and their degradation products.

La présente invention a trait à de nouvelles associations de conservateurs (méthyle et parabens de propyle, phénylméthanol et 2-phénoxyéthanol) qui, selon la BP, l'EP et l'USP ont passé avec sucés les tests antimicrobiens. Les nouveaux conservateurs ont été introduits dans des vaccins utilisant L-histidine comme tampon pour stabiliser le pH à 7,0. Des procédés HPLC ont étés développés pour analyser ces conservateurs et leurs produits de dégradation.

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