Treatment of psychotic and depressive disorders

A - Human Necessities – 61 – K

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Details

A61K 31/496 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2525866

The present invention relates to a method for treating a psychiatric conditions and disorders selected from delusional disorder, psychosis associated with dementia, such as psychosis associated with Alzheimer's disease, psychosis associated with an organic brain syndrome (e.g. stroke, or a viral infection such as an HIV infection), and drug-induced psychosis in mammals, including humans, comprising administering an effective amount of a compound of the formula (I), or a pharmaceutically acceptable acid addition salt thereof, wherein Ar, n, X, and Y are as defined. The present invention also relates to a method for treating a depressive disorder selected from melancholic depression, severe depression, psychotic depression, and treatment- resistant depression in mammals, including humans, comprising administering a compound of formula I, or a pharmaceutically acceptable acid addition salt of such compound.

La présente invention se rapporte à un procédé de traitement de troubles et d'affections d'ordre psychiatrique choisis entre le trouble délirant, la psychose liée à la démence, telle que la psychose liée à la maladie d'Alzheimer, la psychose liée à un syndrome cérébral organique (par exemple une attaque ou une infection virale telle que l'infection à VIH) et la psychose due aux drogues chez les mammifères, y compris les humains, consistant à administrer une quantité efficace d'un composé de la formule (I) ou un sel d'addition d'acide pharmaceutiquement acceptable de ce composé, formule dans laquelle Ar, n, X et Y sont tels que définis. La présente invention se rapporte également un procédé de traitement d'un trouble dépressif choisi entre la mélancolie à forme dépressive, la dépression aiguë, la dépression psychotique et la dépression résistante aux traitements chez les mammifères, y compris les humains, consistant à administrer un composé de la formule (I) ou un sel d'addition d'acide pharmaceutiquement acceptable d'un tel composé.

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