Synthetic peptides and their use as universal carriers for...

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C - Chemistry, Metallurgy

07

K

167/129, 530/13,

C07K 14/445 (2006.01) A61K 39/00 (2006.01) A61K 39/015 (2006.01) A61K 39/385 (2006.01) C07K 7/04 (2006.01) C07K 14/33 (2006.01)

Patent

CA 2006700

CASE 2968/3149 SYNTHETIC PEPTIDES AND THEIR USE AS UNIVERSAL CARRIERS FOR THE PREPARATION OF IMMUNOGENIC CONJUGATES SUITABLE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES ABSTRACT Synthetlc peptides are described having an amino acid sequence corresponding to that of the T epitopes of tetanus toxin and their analo0s able to be recognised by different human T cell clones in a association with a wide range of alleles of the human major histacompatibillty complex (MHC). Said peptides can be used as universal carriers in the preparation of immunogenic conjugates consisting of said peptides and a natural or synthetic hapten derived from a pathogenic agent of interest. The immunogenic conjugates are particularly suitable for preparing synthetic vaccines able to provide a protective immunity against different pathogenic agents which is not genetically restricted or is only slightly genetically restricted.

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