Human proteins having transmembrane domains and dnas...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2327381

A protein comprising any of the amino acid sequences represented by Sequence Nos. 1 to 9, a DNA coding for said protein, exemplified by a cDNA comprising any of the base sequences represented by Sequence Nos. 10 to 18, and an expression vector of said cDNA as well as an eucaryotic cell expressing said cDNA. Said protein and eucaryotic cell having said protein on the membrane surface can be provided by expression of a cDNA coding for a human protein having a transmembrane domain and of a recombinant of the human cDNA.

La présente invention concerne une protéine comprenant l'une quelconque des séquences d'acides aminés représentés par les N?os¿ de séquence 1 à 9. L'invention concerne également un codage ADN destiné à la protéine considérée, illustrée par un ADNc comprenant l'une quelconque des séquences de base représentée par les N?os¿ de séquence 10 à 18. L'invention concerne enfin, d'une part un vecteur d'expression de l'ADNc considéré, et d'autre part une cellule eucaryote exprimant l'ADNc considéré. La protéine considérée ainsi que la cellule eucaryote dont la surface membranaire est pourvue de la protéine considérée peuvent s'obtenir par expression d'un ADNc codant une protéine humaine comportant un domaine transmembranaire et par expression d'une forme d'ADNc humain obtenue par recombinaison.

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