C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 31/715 (2006.01) A61K 38/00 (2006.01) C07K 14/39 (2006.01) C08B 37/00 (2006.01) C12P 7/44 (2006.01) C12P 19/04 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2442923
The present invention provides polysubstituted polycarboxylic phosphoamide biopolymers (PPPBs) comprising polysaccharides and glycopolypeptides attached to a phospho-citrate backbone. Phosphorylation of the biopolymers yields phosphorylated polysubstituted polycarboxylic phosphoamide byopolymers (pPPPBs) which can be used as inflammatory response modulators, immunomodulators and/or biological response modifiers. Methods for producing the PPPBs in yeast subjected to multiple chemical stressors, and uses of compositions derived therefrom, are provided.
L'invention concerne des biopolymères de phosphoamide polycarboxyliques polysubstitués (PPPB) comprenant des polysaccharides et des glycopolypeptides fixés à un squelette de phospho-citrate. La phosphorylation desdits biopolymères produit des byopolymères de phosphoamide polycarboxyliques polysubstitués phosphorylés (pPPPB) pouvant être utilisés comme modulateurs de réponse inflammatoire, immunomodulateurs et/ou modificateurs de réponse biologique. L'invention concerne également des procédés permettant de produire des PPPB dans une levure soumise à de multiples agents d'agression chimique, et les utilisations des compositions dérivées de ces biopolymères.
Granada Bio Tech Sa de Cv
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