Progesterone analogs to reverse multidrug resistance

Details Progesterone analogs to reverse multidrug resistance Progesterone analogs to reverse multidrug resistance

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2225712

The present invention is directed to novel progesterone derivatives, as well as to pharmaceutical compositions thereof, and methods of treatment using the derivatives. More particularly, the invention relates to C7-substituted derivatives of the pregnene series. The present invention is directed to methods of treating multidrug-resistant tumors, and especially breast tumors, with novel C7-substituted progesterone analogs.

Cette invention concerne de nouveaux dérivés de progestérone, leurs compositions pharmaceutiques et les méthodes de traitement dans lesquelles on utilise ces dérivés. L'invention concerne notamment les dérivés substitués en C7 de la série du pregnène. Cette invention concerne les méthodes de traitement de tumeurs à résistance multiple aux anticancéreux, et plus particulièrement dans le cas de tumeurs au sein, avec de nouveaux analogues de progestérone substitués en C7.

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