Imidazolone anorectic agents: i. acyclic derivatives

Details Imidazolone anorectic agents: i. acyclic derivatives Imidazolone anorectic agents: i. acyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 233/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) C07D 233/42 (2006.01) C07D 233/70 (2006.01) C07D 233/72 (2006.01) C07D 233/74 (2006.01) C07D 233/76 (2006.01) C07D 233/78 (2006.01) C07D 233/84 (2006.01) C07D 233/86 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2325588

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of acyclic derivatives of imidazolone compounds of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

On a effectué la synthèse d'une série d'antagonistes non peptidergiques de NPY qui sont composés de dérivés acycliques de composés d'imidazolone représentés par la formule (I). En tant qu'antagonistes du comportement alimentaire provoqué par NPY, ces composés et leurs analogues connus sont susceptibles de jouer un rôle d'agents anorexigènes efficaces afin de favoriser la perte de poids et de traiter des troubles de la nutrition.

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