C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/185 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 209/16 (2006.01) C07D 231/12 (2006.01) C07D 239/26 (2006.01) C07D 261/08 (2006.01) C07D 277/28 (2006.01)
Patent
CA 2554855
The invention relates to a compound having general formula (I), wherein: n = 1 or 2; p represents an integer varying between 1 and 7; A is selected from one or more X, Y and/or Z groups; X = optionally-substituted methylene; Y = C¿2?-alkenylene, optionally substituted, or C¿2?-alkynylene; Z = C¿3-7-?cycloalkyl; G = single bond, O, S, SO, SO¿2?, C=O or CH(OH); R¿1? represents an aryl- or heteroaryl-type group; and R¿2? represents a hydrogen atom or a C¿1-6-?alkyl group; R¿3? represents a hydrogen atom or a C¿1-6?-alkyl, C¿3-7-?-cycloalkyl, C¿3-7?-cycloalkyl-C¿1-3?-alkyl group, said compound taking the form of a base, an acid addition salt, a hydrate or a solvate. The invention also relates to the use thereof as FAAH enzyme inhibitors for the treatment of pain, inflammation, neurodegenerative diseases, etc.
Composé répondant à la formule générale (I): dans laquelle n = 1 ou 2 ; p représente un nombre entier allant de 1 à 7 ; A est choisi parmi un ou plusieurs groupes X, Y et/ou Z ; X = méthylène éventuellement substitué ; Y = C2-alcènylène éventuellement substitué ou C2-alcynylène ; Z = C3-7-cycloalkyle ; G = liaison simple, O, S, SO, SO2, C=O ou CH(OH) ; R1 représente un groupe de type aryle ou hétéroaryle; R2 représente un atome d'hydrogène ou un groupe C1-6-alkyle ; R3 représente un atome d'hydrogène ou un groupe C1-6-alkyle, C3- 7-~cycloalkyle, C3-7-cycloalkyl-C1-3-alkyle ; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat, leur utilisation en tant qu~inhibiteurs de l~enzyme FAAH pour le traitement de la douleur, de l~inflammation, des maladies neurodégénératives etc.
Abouabdellah Ahmed
Almario Garcia Antonio
Hoornaert Christian
Li Adrien Tak
Kirby Eades Gale Baker
Sanofi-Aventis
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