Oligonucleotides comprising alternating segments and uses...

Details Oligonucleotides comprising alternating segments and uses... Oligonucleotides comprising alternating segments and uses...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/712 (2006.01) A61P 31/12 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2474414

The invention relates to oligonucleosides having alternating segments of sugar- modified nucleosides and 2~-deoxynucleosides, and uses thereof. The invention further relates to oligonucleotides having alternating segments of sugar- modified nucleotides and 2~-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, an oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as a component of compositions and commercial packages corresponding to such methods and uses.

L'invention concerne des oligonucléosides comportant des segments alternatifs de nucléosides à sucre modifié et de 2'-désoxynucléosides à sucre modifié, ainsi que leurs utilisations. La présente invention porte également sur des oligonucléotides pourvues de segments alternatifs de nucléotides à sucre modifié et de 2'-désoxynucléotides à sucre modifié, ainsi que sur leurs utilisations. Ces utilisations comprennent la préparation d'oligonucléotides antisens et leur application pour la prévention ou la déplétion de fonction d'un acide nucléique cible d'intérêt, tel que l'ARN, dans un système. Selon l'invention, une oligonucléotide s'avère utile dans des méthodes thérapeutiques, analytiques, des diagnostics et des applications, tout comme composant de préparations et de produits commerciaux correspondant à de telles méthodes et utilisations.

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