Inhibition of the alternative complement pathway for...

Details Inhibition of the alternative complement pathway for... Inhibition of the alternative complement pathway for...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2610340

Disclosed is the use of agents and compositions that selectively inhibit the alternative complement pathway for the inhibiting or treating physiological damage resulting from traumatic brain injury (TBI), spinal cord injury (SCI), or related conditions. Preferred reagents for use in inhibition of damage resulting from TBI or SCI include those that inhibit factor B, with anti- factor B antibodies representing a particularly preferred agent.

L'invention concerne l'utilisation d'agents et de compositions qui inhibent de façon sélective la voie de complément alternative pour l'inhibition ou le traitement de dommages physiologiques qui résultent de lésions traumatiques du cerveau (TBI), de lésions de la moelle épinière (SCI), ou de conditions apparentées. Les réactifs préférés à utiliser pour l'inhibition d'un dommage résultant de TBI ou de SCI comprennent ceux qui inhibent le facteur B, avec des anticorps anti-facteur B représentant un agent particulièrement préféré.

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