Tnf receptor 2 related protein variant

Details Tnf receptor 2 related protein variant Tnf receptor 2 related protein variant

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2453833

The invention provides a cDNA which encodes a TNFR2PV. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer and immune disorders, particularly cancer of the prostate, ovary, breast, colon, and brain, or an inflammatory disorder, including rheumatoid arthritis, asthma, and ulcerative colitis. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

La présente invention concerne un ADNc codant pour une variante de la protéine apparentée au récepteur TNF-2. Cette invention concerne également l'utilisation de l'ADNc, de fragments, de compléments et de variants de celui-ci, ainsi que l'utilisation de la protéine codée, de portions de celle-ci et d'anticorps dirigés contre elle pour diagnostiquer et pour traiter un cancer et des troubles immunitaires, en particulier, le cancer de la prostate, des ovaires, du sein, du colon, du cerveau, ou encore, un trouble inflammatoire, entre autres, la polyarthrite rhumatoïde, l'asthme, et la recto-colite ulcéreuse. En outre, l'invention concerne des vecteurs d'expression et des cellules hôtes permettant la production de la protéine, ainsi qu'un système de modèle transgénique.

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