C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/54 (2006.01) A61K 31/196 (2006.01) A61K 31/245 (2006.01) A61P 29/00 (2006.01) C07C 233/63 (2006.01)
Patent
CA 2677457
A compound of formula (I) wherein X is CH=CH, CH 2O wherein the oxygen atom is bound to ring B or OCH 2wherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF 3and OCF 3. The compound is useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition. A method for preparing the compound.
La présente invention concerne un composé de formule : (I) X R2 O O Y NH O R1 R3 A B (I) 5, où X correspond à CH=CH, CH2O où l'atome d'oxygène est lié au cycle B ou OCH2, où l'atome d'oxygène est lié au cycle A; Y correspond à de l'hydrogène, un alkyle C1-C6 droit ou ramifié, ou un cation inorganique acceptable sur le plan pharmaceutique; R1 correspond à un éthyle ou cyclopropyle; et R2 et R3 sont identiques ou différents et sont sélectionnés parmi F, Cl, Br, CF3 et OCF3. Le composé sert à traiter les maladies auto-immunes, inflammatoires, les rejets de greffes d'organes (10) et les néoplasies malignes. L'invention se rapporte à une composition pharmaceutique. L'invention a trait en outre à un procédé de préparation du composé.
Fritzson Ingela
Hallin Ingrid
Svensson Leif
Tuvesson Andersson Helen
Vellmar Ulf
Chelsea Therapeutics Inc.
Ridout & Maybee Llp
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