C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/00 (2006.01) C07K 14/29 (2006.01) C12N 9/02 (2006.01) C12N 9/52 (2006.01)
Patent
CA 2375650
This invention provides the sequence of 5,300 nucleotides from the E. canis genome. There are four proteins, ProA, ProB, ORF, and a cytochrome oxidase homolog, as well as a partial lipoprotein signal peptidase homolog at the carboxy terminus, coded for in this cloned fragment. The antigenic properties of these proteins allow them to be used to create a vaccine. An embodiment of this invention includes the creation of a DNA vaccine, a recombinant vaccine, and a T cell epitope vaccine.
Cette invention concerne la séquence de 5300 nucléotides tirée du génome d'E. canis. Il existe 4 protéines, ProA, ProB, ORF, ainsi qu'un homologue de cytochrome oxydase, et un homologue partiel de peptidase signal lipoprotéique sur la terminaison carboxy, codées pour ce fragment cloné. Les propriétés antigéniques de ces protéines permettent leur utilisation pour créer un vaccin. Un mode de réalisation de cette invention comprend la création d'un vaccin à ADN, d'un vaccin recombiné et d'un vaccin à épitope de lymphocytes T.
Borden Ladner Gervais Llp
Cornell Research Foundation Inc.
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