C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2330842
Truncated Apaf-1 nucleic acids and encoded polypeptides are provided. Also provided are self-oligomerizing caspase molecules capable of self-processing. In one embodiment the present invention provides methods for identifying apoptotic inhibitors and enhancers use whole cell or reconstituted component assay systems. In a further embodiment, truncated Apaf-1 and self- oligomerizing caspase constructs are described which can be provided to a cell, thereby inducing apoptosis.
L'invention concerne des acides nucléiques et des polypeptides codés d'Apaf-1 tronquée. L'invention concerne également des molécules de caspase auto-oligomérisantes capables d'un auto-traitement. Dans un mode de réalisation, la présente invention concerne des méthodes d'identification d'inhibiteurs et d'activateurs apoptiques utilisant des systèmes de dosage de cellules entières ou de constituants reconstitués. Dans un autre mode de réalisation, des constructions d'Apaf-1 tronquée et de caspase auto-oligomérisante sont décrites, lesquelles peuvent être fournies à une cellule, induisant ainsi l'apoptose.
Gowling Lafleur Henderson Llp
Thomas Jefferson University
LandOfFree
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