Seco-mevinic acid derivatives useful as...

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C - Chemistry, Metallurgy

07

D

167/179, 260/356

C07D 309/30 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 69/30 (2006.01) C07C 69/675 (2006.01) C07C 69/732 (2006.01) C07D 319/06 (2006.01) C07D 405/08 (2006.01) C07D 407/08 (2006.01) C07D 409/08 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2023857

HX27 Abstract SECO-MEVINIC ACID DERIVATIVES USEFUL AS ANTIHYPERCHOLESTEROLEMIC AGENTS AND NEW INTERMEDIATES Seco-mevinic acid derivatives are provided which have the structure Image including all stereoisomers thereof, wherein Z is Image or Image R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroaryl, aralkyl, heteroaralkyl or heterocyclic; R2 is lower alkyl, cycloalkyl or aralkyl, and X is O or NR5 wherein R5 is H ox lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as HX27 antihypercholesterolemic agents and in treating atherosclerosis. New intermediates for preparing the above seco-mevinic acid derivatives are also provided.

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