Polymeric delivery of radionuclides and radiopharmaceuticals

A - Human Necessities – 61 – K

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A61K 51/06 (2006.01) A61K 51/04 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2248076

Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

L'invention concerne des polymères appliqués localement et utilisés comme vecteur pour l'immobilisation et l'administration d'un radionucléide ou d'un produit radiopharmaceutique. Les radionucléides sont incorporés au polymère sous leur forme élémentaire, comme composés minéraux, fixés à des molécules plus grandes ou par des méthodes physiques ou chimiques. Une structure auxiliaire peut être utilisée pour assurer la modulation de la vitesse de libération. On peut utiliser les radionucléides habituellement utilisés pour les radiothérapies locales, tels que l'iode, l'iridium, le radium, le césium, l'yttrium et d'autres éléments.

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